Is daptomycin lipophilic
WebFeb 6, 2012 · Lipoglycopeptides contain a lipophilic side chain that varies among the compounds of this class. This lipophilic chain confers a longer half-life and converts these agents (with the exception of dalbavancin) into concentration-dependent bactericidal antibiotics. 213 These compounds have greater potency against gram-positive cocci than ... WebMar 16, 2024 · Daptomycin is a lipoglycopeptide antibiotic with potent bactericidal activity against most gram-positive infections, with current indications for treatment of skin and soft tissue infections and Staphylococcus aureus bloodstream infections, but it also has been used off-label for many infections including osteomyelitis and prosthetic joint infections …
Is daptomycin lipophilic
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WebMar 7, 2024 · Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such as methicillin-resistant … http://www.jsirjournal.com/Vol2Issue5019.pdf
WebFor research use only. Daptomycin (Cubicin,LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. CAS No. 103060-53-3 Selleck's Daptomycin (LY146032) has been cited by 20 publications Molecules,202428 (2)621 Comput Struct Biotechnol J,202420:2442-2454 J Phys Chem B,2024125 (22):5775-5785 WebDec 14, 2024 · The extravascular distribution of daptomycin is limited due to its negative charge at physiological pH, its low lipophilicity, and its high binding to plasma proteins. The volume of distribution of total daptomycin is approximately 0.1 L/kg for healthy volunteers [ …
Web1 day ago · GISA and daptomycin-resistant strains, ... lipophilic teicoplanin and ristocetin aglycon derivatives with high antibacterial and anti-influenza virus activity: an aggregation and receptor binding ... WebNov 19, 2010 · Daptomycin is a lipopeptide antibiotic with a unique mechanism of action on Gram-positive bacteria. It is approved for treatment of skin and soft-tissue infections with …
Webthe causative pathogens and to determine their susceptibility to daptomycin. To reduce the development of drug-resistant bacteria and maintain the effectiveness of CUBICIN and …
WebDaptomycin. Daptomycin is a cyclic lipopeptide antibiotic that has a unique mechanism of action. It binds to the bacterial cell membranes, causing rapid depolarization of the membrane due to potassium efflux and associated disruption of DNA, RNA, and protein synthesis; the result is rapid concentration-dependent bacterial death. star free trialWebOct 15, 2024 · Although risk factors for daptomycin-associated myopathy are poorly defined, creatine phosphokinase (CPK) monitoring and temporary discontinuation of 3-hydroxy-3 … starfresh agro parkWebAug 27, 2016 · Daptomycin is approved for the treatment of MRSA-linked complicated skin and skin-structure infections (cSSSIs) and bacteraemia, including right-sided endocarditis. The mode of action is not well understood, but involves disruption of the cell wall of Gram positive bacteria after insertion of daptomycin, facilitated by its lipophilic ‘ tail ’. starfresherWebApr 1, 2009 · Daptomycin is a lipopeptide antibiotic used clinically to treat infections caused by Gram-positive bacteria. Laboratory studies have shown that Staphylococcus aureus resistance to daptomycin... star frescoWebDaptomycin Hydrophilic Colistimethate (Polymyxin) Hydrophilic Lipophilic agents 1. Large volume of distribution 2. Hepatic metabolism 3. Achieves intracellular concentrations 4. … starfresh directWebJan 1, 2024 · Reconstitution of Daptomycin for Injection Vial. Daptomycin for injection is supplied in single-dose vials, each containing 350 mg daptomycin as a sterile, lyophilized … star freight services pty ltdpeterborough pe2 7ea